Abstrait

Pharmacological and Toxicological Screening of Novel Benzimidazole- Morpholine Derivatives as Dual-Acting Inhibitors

Mahesh M Coloma

The end of this study was to probe acetylcholinesterase(pang), monoamine oxidase A(MAO- A), monoamine oxidase B(MAO- B), cyclooxygenase- 1(COX- 1) and cyclooxygenase- 2(COX- 2) enzyme inhibitory, and antimicrobial conditioning of a new series of 2-(4- substituted phenyl)- 1-(2-(morpholin-4-yl) ethyl)- 1H- benzimidazole derivations, for their possible use asmulti-action remedial agents. Target composites(n = 15) were synthesized under microwave oven irradiation conditions in two way, and their structures were illustrated by FT- IR, 1H- NMR, 13C- NMR and high resolution mass spectroscopic analyses. Pharmacological webbing studies revealed that two of the composites(2b and 2j) have inhibitory eventuality on both COX- 1 and COX- 2 enzymes. In addition, cytotoxic and genotoxic parcels of the composites 2b, 2j and 2m were delved via the well- known MTT and Ames tests, which revealed that the mentioned composites arenon-cytotoxic andnon-genotoxic. As a terse conclusion, two new composites were characterized as implicit campaigners for treatment of constantly encountered seditious conditions