Abstrait
Treatment algorithms for hypertension: a practical approach
Joel M NeutelRenin–angiotensin system inhibitors, calcium channel blockers and diuretics
are the mainstay of current antihypertensive therapy. Patient characteristics are likely to
influence the individual response to these agents, although the majority of patients require
dual therapy to meet blood pressure goals and some require triple therapy. Combination
with complementary modes of action, and may reduce side-effect burden. Typically, patients
who require combination therapy will have comorbidities that influence the preferred
antihypertensive class for their treatment. Single-pill combinations can offer practical benefits,
but lack dose flexibility and may not comprise drug classes that are optimal for a specific patient.
The management of patients who require multiple therapies, therefore, involves weighing the
benefits of convenience against the need to select therapies based on a consideration of
therapeutic indications.
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