Abstrait

A review on pharmaceutically relevant proteins

Ines Sebastian

The production of biopharmaceuticals is on the rise. Multiple diseases require them for treatment and prevention. In order to produce biopharmaceuticals more effectively, an urgent need has been identified for process intensification in downstream processing (DSP). The majority of the costs associated with producing pharmaceutically relevant proteins are currently covered by the DSP. This brief overview brings together important research from the past three years that looks at novel ways to get around this bottleneck. The overview includes promising research on the purification of pharmaceutically relevant proteins using chromatography, aqueous two-phase systems, precipitation, crystallization, magnetic separation, and filtration.